Diuretics and Thyroid disorders Quiz covers pharmacology of diuretics and thyroid disorders, including hypothyroidism and hyperthyroidism. Matt2425 published on April 10, 20138 responses 0 Questions in vertical order Which mechanism of action best describes loop diuretics? Loop diuretics bind to the Cl- site of the Na+/Cl- transporter and blocks its action. Loop diuretics alter the osmotic equilibrium of the solute, causing fluid to collect in the lumen. Loop diuretics increases the efflux of HCO3- into the lumen Loop diuretics bind to Cl- site of Na+/K+/ATPase to enhance salt excretion. A patient with peripheral oedema, high plasma K+ concentrations who has had a history of CHF also has osteoporosis. Which of the following diuretics is best indicated for her condition? Spironolactone Indapamide Mannitol Ethacrynic acid What is NOT a primary function of the thyroid hormone? Metabolism of cholesterol Brain development Slowing of heart Enhances consumption of O2 Indicate whether these statements are true or false:1) Thiazides are indicated in treatment of renal calculi.2) Hyperuricaemia is an adverse effect of thiazide use. 1) True; 2) True 1) True; 2) False 1) False; 2) True 1) False; 2) False Which symptom is generally not conclusive in diagnosis of hyperthyroidism or hypothyroidism? Weight loss Tachycardia Swelling of eyes Goiter Which pair of drug classes is contraindicated in pregnancy? Spironolactone and carbonic anhydrase inhibitors Loop diuretics and sulfonamides Osmotic diuretics and thiazides Spironolactone and loop diuretics What is the mechanism of action of carbimazole? It prevents the conversion of inactive T3 to active T4 (thyroxine). It is an antithyroid drug that inhibits thyroperoxidase to prevent formation of iodothyronines via iodotyrosyl residue coupling. Inhibits release of thyroid hormone from the gland. It prevents deiodination of thyroxine into T3. Which of the following is NOT a consideration when prescribing diuretics to the elderly? Diuretics may increase urinary incontinence Kidney function decreases with age The drug may be take longer to act necessitating a higher dose of the drug Management of fluid intake Which of the following indicates the correct order of thyroid hormone secretion? Hypothalamus (TRH) --> Anterior Pituitary (TSH) --> Thyroid (T4/T3) Anterior Pituitary (TRH) --> Hypothalamus (TSH) --> Thyroid (T4/T3) Thyroid (TRH) --> Hypothalamus (TSH) --> Anterior Pituitary (T3/T4) Hypothalamus (TRH) --> Thyroid (TSH) --> Anterior Pituitary (T4/T3) What is one limitation of using thyroid hormone replacement therapy? Thyroxine has a short half life and so needs to be taken several times a day It cannot be taken orally and must be injected subcutaneously. T4 does not readily interconvert to T3 in the body. Thyroid replacement suppresses TSH and reduces thyroid function. Which of the following are adverse effects of using a loop diuretic? Gout, headache, dizziness, rash, hypotension Hypokalemia, metabolic acidosis, diarrhoea Renal impairment, headache, gynaecomastia GI upset, hypotension, hypocalcaemia, hyperkalemia Which drug is NOT matched with its region of action? Thiazide, distal convulated tubule Loop diuretic, thick ascending loop of Henle K+ sparing diuretics, thin ascending loop of Henle Carbonic anhydrase inhibitors, proximal convulated tubule What are the possible side effects of using carbimazole or propylthiouracil? Click on all the correct ones. Select the two correct answers Weight loss Swelling of the eyes Agranulocytosis Anorexia Name another example of a K+ sparing diuretic other than spironolactone Type answer (9 letters) Which diuretic is known to limit K+ excretion and in which condition is it contraindicated? Spironolactone, taking of an ACE-I Mannitol, glaucoma Furosemide, diarrhoea Acetazolamide, lactic acidosis Metabolic acidosis from carbonic anhydrase inhibitors is a mainly a result of: High levels of associating CO2 and H2O to form carbonic acid (H2CO3) Low levels of CO2 in plasma High levels of bicarbonate filtered out. High volume of water lost concentrates protons.